Mouse Anti-Human CA125 Monoclonal Antibody, clone C13754, cap/det
Cat No | BSMA-4335-C |
Conjugate | |
Type | 抗體對 |
Clone | C13754 |
Source | Mouse |
Tag | N/A |
Size | 1 mg |
Application | CLIA |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 1×PBS, pH 7. 4. |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | 糖類抗原125;CA125;CA-125;MUC16;CA 125;CA12-5;CA 125CA-125;CA125CA125 ovarian cancer antigen;Cancer antigen 125;FLJ14303;MUC 16;MUC-16;MUC16;MUC16_HUMAN;Mucin 16;Mucin 16 cell surface associated;Mucin-16;Mucin16;Ovarian cancer related tumor marker CA125;Ovarian cancer-related tumor marker CA125;Ovarian carcinoma antigen CA125 |
Purification | > 95% |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | Recommended Antibody pairs:BSMA-4335-C- BSMA-4335-D; BSMA-4335-D- BSMA-4335-C |
Background | 糖類抗原125(CA125)是一種以O(shè)鍵為主的糖蛋白, 由MUC16基因編碼, 是粘蛋白16(MUC16)上的串聯(lián)重復(fù)結(jié)構(gòu)城的不連續(xù)表位. 在自然條件下, 它是一個非常大的復(fù)合體(可能多達(dá)400萬Da, 核心CA125亞單位超過20萬Da), CA125由于其固有的內(nèi)源性蛋白酶活性而發(fā)生白蛋白分解, 它的胞外城水解后釋放到細(xì)胞外間質(zhì), 進(jìn)入循環(huán)系統(tǒng). CA125釋放之前發(fā)生磷酸化, 釋放時去磷酸化. CA125的釋放或分泌與上皮生長因子受體信號轉(zhuǎn)導(dǎo)通路直接相關(guān), 研究表明, CA125對卵巢瘤細(xì)胞的遷移有顯著影響; 另外CA125存在時會抑制自然殺傷(NK)細(xì)胞功能. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.