Rabbit Anti-IGSF6 Polyclonal Antibody
Cat No | BIOS-1083P |
Conjugate | |
Type | 多克隆抗體 |
Source | Rabbit |
Size | 1mg |
Application | WB |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 0.01 M PBS; pH 7.4. |
Storage | Store at -20 degree for long term. |
Synonyms | IGSF6;DORA |
Purification | Affinity purification |
MolecularWeight | 30KDa |
Description | |
Background | IGSF6 (DORA); a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA; we isolated a cosmid which contains the entire mouse gene. By comparative analysis and reverse transcriptase polymerase chain reaction; we defined the intron/exon structure and the mRNA of the mouse gene and; with respect to human BAC clones; the human gene. The genes span 10 kb (mouse) and 12 kb (human); with six exons arranged in a manner similar to other members of the IGSF. All intron/exon boundaries follow the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to cells of the immune system; particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb; in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb. The human and mouse genes were localized to a locus associated with inflammatory bowel disease. Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene; transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron. An identical organization is seen in human. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.