Background | HO-PEG-Mal, MW 2,000 is a thiol reactive PEG polymer. The PEG is water soluble and hydroxyl moiety allows further modification with other reactive group.HO-PEG-mal (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |