Background | PLGA is widely used in bone tissue engineering due to its suitable physico-chemical properties and biodegradability rate; however, compared to natural polymerssuch as collagen and chitosan which have numerous ionic molecular groups, the synthetic polymers have relatively few of these groups, making it very difficult to induce mineralization. PLGA nanoparticles can improve the therapeutic efficacy of gene delivery due to sustained and controlled release of the encapsulated DNA over a period of days to several weeks compared with natural polymers. Further, PLGA has been approved by the US FDA and the European Medicine Agency in drug delivery systems for parenteral administration. |