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抗體產(chǎn)品
- 一抗
  - --|--|流式抗體
  - --|--|單克隆抗體
  - --|--|重組兔單抗
  - --|--|多克隆抗體
  - --|--|小分子抗原抗體
  - --|--|抗體對
  - --|--|標簽抗體
  - --|--|修飾性抗體
  - --|--|其他抗體
- 二抗
- 試劑盒
  - --|--|標記試劑盒
  - --|--|其他試劑盒
  - --|--|ELISA試劑盒
  - --|--|標記染料
蛋白產(chǎn)品
生物材料
- 金屬納米材料
  - --|--|金納米球
  - --|--|金納米棒
  - --|--|銀納米球
  - --|--|金納米海膽
  - --|--|碳納米顆粒
  - --|--|特殊納米顆粒
- 熒光微球
  - --|--|紅色熒光微球
  - --|--|橙色熒光微球
  - --|--|綠色熒光微球
  - --|--|藍色熒光微球
  - --|--|AIE熒光微球
  - --|--|其他熒光微球
- 磁性微球
  - --|--|PS磁性微球
  - --|--|SiO2磁性微球
  - --|--|Fe3O4磁性微球
  - --|--|功能化磁性微球
  - --|--|Magnetic Particles Conjugates
  - --|--|磁性微球試劑盒
  - --|--|其他磁性微球
- 單分散微球
  - --|--|PS微球/聚苯乙烯-100%純度
  - --|--|Silica微球/ 二氧化硅-100%純度
  - --|--|PMMA微球/聚甲基丙烯酸甲酯-100%純度
  - --|--|PET微球/聚對苯二甲酸乙二醇酯-模版法
  - --|--|PVA微球/聚乙烯醇-模版法
  - --|--|PVC微球/聚氯乙烯-100%純度/模版法
  - --|--|DVB微球/二乙烯基苯
  - --|--|PP微球/聚丙烯-模版法
  - --|--|PE微球/聚乙烯-模版法
  - --|--|GMA微球/甲基丙烯酸環(huán)氧丙脂-100%純度
  - --|--|PLA微球/聚乳酸-100%純度
  - --|--|PLGA微球/聚乙丙交酯-100%純度
  - --|--|PLLA微球/聚左旋乳酸-100%純度
  - --|--|PDLA微球/聚右旋乳酸-100%純度
  - --|--|PCL微球/聚己內(nèi)酯-100%純度
  - --|--|PTFE微球/聚四氟乙烯-100%純度
  - --|--|PBS微球聚丁二酸丁二醇酯-100%純度
  - --|--|Polydopamine微球聚多巴胺-100%純度
  - --|--|各向異性janus粒子
  - --|--|Sodium Alginate微球/海藻酸鈉
  - --|--|Agarose微球/瓊脂糖
  - --|--|Polymethylsilsesquioxane微球/聚甲基倍半硅氧烷
  - --|--|PBAT微球/聚己二酸-對苯二甲酸丁二醇酯
- 染色微球
  - --|--|黃色染色微球
  - --|--|黑色染色微球
  - --|--|紅色染色微球
  - --|--|綠色染色微球
  - --|--|紫色染色微球
  - --|--|藍色染色微球
- 其他材料
  - --|--|上轉換納米顆粒
  - --|--|量子點
  - --|--|色譜填料
  - --|--|纖維素微球
  - --|--|介孔材料
熱銷產(chǎn)品
- 猴痘相關產(chǎn)品
- 新冠相關產(chǎn)品
- 外泌體相關產(chǎn)品
- 常用試劑
  - --|--|轉染試劑
  - --|--|ELISA-FCM試劑
  - --|--|WB試劑
  - --|--|IHC-ICC-IF試劑
  - --|--|載體材料

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Recombinant Human IFNAR2/IFNARB Protein, Fc-His

Description
Documentation
Citations

Cat No	BIOP3452
Conjugate
Type	細胞因子
Source	HEK293
Tag	Fc-His
Size	20 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	IFNAR2;IFNARB;IFNABR;IFN-R-2
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description
Background	Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family.Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human IFNAR2/IFNARB Protein, Fc-His