Recombinant Rabbit Anti-Cleaved-Caspase 3 p17 Monoclonal Antibody, clone BT2945
Cat No | BQSB-1001 |
Conjugate | |
Type | 重組兔單抗 |
Clone | BT2945 |
Source | Rabbit |
Tag | N/A |
Size | 1 mg |
Application | IHC-F; IHC-P; IF |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Synonyms | 活化半胱胺酸蛋白酶蛋白-3;Caspase-3 subunit p17;cleaved Caspase 3;cleaved Caspase-3;APOPAIN;CASP3;Caspase 3 apoptosis related cysteine protease;Caspase3;CPP32;CPP32B;Cysteine protease CPP32;Human cysteine protease CPP32 isoform alpha mRNA complete cds;PARP cleavage protease;SCA 1;SCA1;SREBP cleavage activity 1;Yama;CASP3_HUMAN;Caspase-3;CASP-3;Apopain;Protein Yama;SREBP cleavage activity 1 |
Purification | |
MolecularWeight | |
Description | |
Background | The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC; Biotin; Alexa Fluor; Rhodamine B; Cy; Co-Au.