Recombinant RIPK1 Protein
Cat No | BQSB-3042 |
Conjugate | |
Type | 重組蛋白 |
Source | E. coli |
Tag | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Size | 20 ug |
Application | Immunology |
Format | Liquid |
Buffer | Supplied in PBS. |
Species | Human |
Storage | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Synonyms | eceptor-interacting protein 1;Receptor-interacting serine/threonine-protein kinase 1;Rinp;RIP 1;RIP;Rip-1;RIP1;RIPK 1;Ripk1;RIPK1_HUMAN;Serine threonine protein kinase RIP;Serine/threonine-protein kinase RIP |
Purification | |
MolecularWeight | 49.4 kDa |
Description | |
Background | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway. Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis. RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC; Biotin; Alexa Fluor; Rhodamine B; Cy; Co-Au.