Recombinant Rabbit Anti-IL-17A Monoclonal Antibody, clone BT2680, cap
Cat No | BQSB-732-C |
Conjugate | |
Type | 抗體對 |
Clone | BT2680 |
Source | Rabbit |
Tag | N/A |
Size | 1 mg |
Application | ELISA |
ApplicationNote | Recommended Antibody pairs: BQSB-732-C-BQSB-732-D |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Synonyms | Neurogenic locus notch homolog protein 1;Notch 1 extracellular truncation;Notch 1 intracellular domain;hN1;Lin-12;LIN12;MIS6;Motch A;mT14;Neurogenic locus notch homolog protein 1;Neurogenic locus notch protein homolog;NICD;Notch1 intracellular domain;NOTC1_HUMAN;Notch 1;NOTCH;Notch gene homolog 1 (Drosophila);Notch homolog 1 translocation associated (Drosophila);Notch homolog 1, translocation-associated (Drosophila);NOTCH, Drosophila, homolog of, 1;p300;TAN 1;TAN1;Translocation Associated Notch Homolog |
Purification | |
MolecularWeight | |
Description | |
Background | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC; Biotin; Alexa Fluor; Rhodamine B; Cy; Co-Au.