Recombinant Rabbit Anti-5HT2C Monoclonal Antibody, clone BT2914
Cat No | BQSB-970 |
Conjugate | |
Type | 重組兔單抗 |
Clone | BT2914 |
Source | Rabbit |
Tag | N/A |
Size | 1 mg |
Application | WB |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Synonyms | 5-羥色胺受體2C;Transferrin receptor protein 1;Transferrin receptor;CD71;CD 71;CD71 antigen;p90;T9;TFR 1;TFR;TFR1;TR;sTfR;Transferrin receptor (p90 CD71);TRFR;TFR1_HUMAN |
Purification | |
MolecularWeight | |
Description | |
Background | Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC; Biotin; Alexa Fluor; Rhodamine B; Cy; Co-Au.