Axl, His
Cat No | BSA-0072A |
Conjugate | |
Type | 重組蛋白 |
Source | Mammalian cell |
Tag | His |
Size | 1 mg |
Application | Immunogen; Calibrator; Standard |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 1×PBS, pH 7. 4. |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | 酪氨酸蛋白激酶受體;AXL;Axl;Ark;Ufo;Tyro-7 |
Purification | > 90% by SDS-PAGE |
Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
MolecularWeight | |
Description | |
Background | 酪氨酸蛋白激酶受體(Axl)又名Ark、Ufo和Tyro-7, 是一種細(xì)胞表面的跨膜受體, Axl的相對(duì)分子量約為140KD. 由分布在44kb區(qū)城的20個(gè)外顯子編碼, 基因位于第19號(hào)染色體. 分子分為胞外區(qū)、胞內(nèi)區(qū)和跨脯區(qū)3部分:其中胞外區(qū)包括2個(gè)免疫球蛋白樣區(qū)(lg)和2個(gè)纖連蛋白Ⅲ(FNⅢ)樣區(qū). Ig樣區(qū)是配體結(jié)合區(qū), FNⅢ區(qū)在AxJ與配體結(jié)合的過程中起調(diào)節(jié)作用. Axl的胞外區(qū)與神經(jīng)細(xì)胞貼附分子結(jié)構(gòu)相似; 且胞內(nèi)區(qū)有酪氨酸激醇活性, 所以Axl可促進(jìn)細(xì)胞粘附和增殖. Axl與配體生長停滯特異性基因6(Gas6)蛋白結(jié)合, 發(fā)生磷酸化, 磷酸化位點(diǎn)與相應(yīng)蛋白結(jié)合, 激活下游信號(hào)轉(zhuǎn)導(dǎo)通路, 進(jìn)而發(fā)揮促進(jìn)細(xì)胞增殖、抗凋亡、遷移、侵襲等生物學(xué)功能. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.